![]() minute ventilation corrected for physiologic dead space. Increased metabolic demands, as shown by the VeqO(2), VeqCO(2), and ventilatory support, are the major determinants of E requirements in children with ARDS. TV tidal volume (mL) RR respiratory rate (breaths/min) Alveolar Ventilation. Increased VD/VT was the main cause of the excess of E demand in these patients. When compared to non-ARDS patients (33 patients), the patients with ARDS (12 patients) had a significantly higher VeqO(2) (3.3 +/- 1 vs 2.8 +/- 1 L per 100 mL, respectively p < 0.05), a significantly higher VeqCO(2) (3.7 +/- 1 L/100 vs 3.1 +/- 1 L per 100 mL, respectively p < 0.05), and a significantly higher VD/VT (0.62 +/- 0.14 vs 0.43 +/- 0.15, respectively p < 0.0005).Ĭritically ill children with ARDS have increased VD/VT. The group mean (+/- SD) ventilatory equivalent for oxygen (VeqO(2)) and ventilatory equivalent for carbon dioxide (VeqCO(2)) were 2.9 +/- 1 and 3.3 +/- 1 L per 100 mL, respectively. ARDS was defined based on criteria by The American-European Consensus Conference. ![]() VD/VT parameters were calculated using the modified Bohr-Enghoff equation. Indirect calorimetry was used to measure metabolic parameters. The purpose of this study was to measure metabolic parameters and VD/VT in critically ill children.Ī total of 45 mechanically intubated children (mean age, 5.5 years). Mechanical ventilation with positive end-expiratory pressure, when used in critically ill patients to correct hypoxemia, may contribute to increased VD/VT. ![]() In children with acute lung injury, there is an increase in minute ventilation (E) and inefficient gas exchange due to a high level of physiologic dead space ventilation (VD/VT). ![]()
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